Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis

Hypothalamic leptin signaling plays a central role in maintaining body weight homeostasis. Here, we show that clusterin/ApoJ, recently identified as an anorexigenic neuropeptide, is an important regulator in the hypothalamic leptin signaling pathway. Coadministration of clusterin potentiates the ano...

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Autori principali: Byun, Kyunghee, Gil, So Young, Namkoong, Churl, Youn, Byung-Soo, Huang, Hu, Shin, Mi-Seon, Kang, Gil Myoung, Kim, Hyun-Kyong, Lee, Bonghee, Kim, Young-Bum, Kim, Min-Seon
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196984/
https://ncbi.nlm.nih.gov/pubmed/24825475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201338317
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