Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

BACKGROUND: ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer’s disease has been widely studied, although the source and concentration of ApoJ that promotes or inhibits Aβ cere...

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Bibliografski detalji
Izdano u:Alzheimers Res Ther
Glavni autori: de Retana, Sofía Fernández, Marazuela, Paula, Solé, Montse, Colell, Guillem, Bonaterra, Anna, Sánchez-Quesada, Jose Luis, Montaner, Joan, Maspoch, Daniel, Cano-Sarabia, Mary, Hernández-Guillamon, Mar
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511153/
https://ncbi.nlm.nih.gov/pubmed/31077261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0498-8
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