Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling

Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. Here we report that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Lepti...

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Bibliographic Details
Main Authors: Huang, Hu, Kong, Dong, Byun, Kyung Hee, Ye, Chianping, Koda, Shuichi, Lee, Dae Ho, Oh, Byung-Chul, Lee, Sam W, Lee, Bonghee, Zabolotny, Janice M, Kim, Min Seon, Bjørbæk, Christian, Lowell, Bradford B, Kim, Young-Bum
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458121/
https://ncbi.nlm.nih.gov/pubmed/22941110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3207
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