Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling

Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. Here we report that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Lepti...

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Bibliografski detalji
Glavni autori: Huang, Hu, Kong, Dong, Byun, Kyung Hee, Ye, Chianping, Koda, Shuichi, Lee, Dae Ho, Oh, Byung-Chul, Lee, Sam W, Lee, Bonghee, Zabolotny, Janice M, Kim, Min Seon, Bjørbæk, Christian, Lowell, Bradford B, Kim, Young-Bum
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458121/
https://ncbi.nlm.nih.gov/pubmed/22941110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3207
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