Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity

Cells respond to shrinkage induced by increased extracellular osmolarity via programmed changes in gene transcription and mRNA translation. The immediate response to this stress includes the induction of expression of the neutral amino acid transporter SNAT2. Increased SNAT2-mediated uptake of neutr...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Krokowski, Dawid, Jobava, Raul, Guan, Bo-Jhih, Farabaugh, Kenneth, Wu, Jing, Majumder, Mithu, Bianchi, Massimiliano G., Snider, Martin D., Bussolati, Ovidio, Hatzoglou, Maria
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505033/
https://ncbi.nlm.nih.gov/pubmed/26041779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.636217
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