Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

Overexpression of antiapoptotic Bcl-2 proteins such as Bcl-2, Bcl-xL, and Mcl-1 is widely associated with tumor initiation, progression, and chemoresistance. Furthermore, it has been demonstrated that Mcl-1 upregulation renders several types of cancers resistant to the Bcl-2/Bcl-xL inhibitors ABT-73...

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Publicat a:Blood
Autors principals: Pan, Rongqing, Ruvolo, Vivian R., Wei, Jun, Konopleva, Marina, Reed, John C., Pellecchia, Maurizio, Andreeff, Michael, Ruvolo, Peter P.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504949/
https://ncbi.nlm.nih.gov/pubmed/26045609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-604975
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