Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay

BACKGROUND: Myostatin is a protein synthesized and secreted by skeletal muscle that negatively regulates muscle mass. The extent to which circulating myostatin levels change in the context of aging is controversial, largely due to methodological barriers. METHODS: We developed a specific and sensiti...

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Detalhes bibliográficos
Publicado no:Skelet Muscle
Main Authors: Bergen, H. Robert, Farr, Joshua N., Vanderboom, Patrick M., Atkinson, Elizabeth J., White, Thomas A., Singh, Ravinder J., Khosla, Sundeep, LeBrasseur, Nathan K.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502935/
https://ncbi.nlm.nih.gov/pubmed/26180626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-015-0047-5
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