Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay

BACKGROUND: Myostatin is a protein synthesized and secreted by skeletal muscle that negatively regulates muscle mass. The extent to which circulating myostatin levels change in the context of aging is controversial, largely due to methodological barriers. METHODS: We developed a specific and sensiti...

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Bibliographische Detailangaben
Veröffentlicht in:Skelet Muscle
Hauptverfasser: Bergen, H. Robert, Farr, Joshua N., Vanderboom, Patrick M., Atkinson, Elizabeth J., White, Thomas A., Singh, Ravinder J., Khosla, Sundeep, LeBrasseur, Nathan K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502935/
https://ncbi.nlm.nih.gov/pubmed/26180626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-015-0047-5
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