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Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF

Recent evidence suggests that autophagy may favor fibrosis through enhanced differentiation of fibroblasts in myofibroblasts. Here, we sought to characterize the mediators and signaling pathways implicated in autophagy-induced myofibroblast differentiation. Fibroblasts, serum starved for up to 4 d,...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Autophagy
Prif Awduron: Bernard, Monique, Dieudé, Mélanie, Yang, Bing, Hamelin, Katia, Underwood, Katy, Hébert, Marie-Josée
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502773/
https://ncbi.nlm.nih.gov/pubmed/25495560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15548627.2014.981786
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