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Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis.

The activation of conditional alleles of Myc induces both cell proliferation and apoptosis in serum-deprived RAT1 fibroblasts. Entry into S phase and apoptosis are both preceded by increased levels of cyclin E- and cyclin D1-dependent kinase activities. To assess which, if any, cellular responses to...

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Hlavní autoři: Rudolph, B, Saffrich, R, Zwicker, J, Henglein, B, Müller, R, Ansorge, W, Eilers, M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC450247/
https://ncbi.nlm.nih.gov/pubmed/8670807
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