MAD1 and p27(KIP1) Cooperate To Promote Terminal Differentiation of Granulocytes and To Inhibit Myc Expression and Cyclin E-CDK2 Activity

To understand how cellular differentiation is coupled to withdrawal from the cell cycle, we have focused on two negative regulators of the cell cycle, the MYC antagonist MAD1 and the cyclin-dependent kinase inhibitor p27(KIP1). Generation of Mad1/p27(KIP1) double-null mice revealed a number of synth...

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Detalhes bibliográficos
Main Authors: McArthur, Grant A., Foley, Kevin P., Fero, Matthew L., Walkley, Carl R., Deans, Andrew J., Roberts, James M., Eisenman, Robert N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133749/
https://ncbi.nlm.nih.gov/pubmed/11940659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.3014-3023.2002
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