MAD1 and p27(KIP1) Cooperate To Promote Terminal Differentiation of Granulocytes and To Inhibit Myc Expression and Cyclin E-CDK2 Activity

To understand how cellular differentiation is coupled to withdrawal from the cell cycle, we have focused on two negative regulators of the cell cycle, the MYC antagonist MAD1 and the cyclin-dependent kinase inhibitor p27(KIP1). Generation of Mad1/p27(KIP1) double-null mice revealed a number of synth...

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Autores principales: McArthur, Grant A., Foley, Kevin P., Fero, Matthew L., Walkley, Carl R., Deans, Andrew J., Roberts, James M., Eisenman, Robert N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC133749/
https://ncbi.nlm.nih.gov/pubmed/11940659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.3014-3023.2002
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