MAD1 and p27(KIP1) Cooperate To Promote Terminal Differentiation of Granulocytes and To Inhibit Myc Expression and Cyclin E-CDK2 Activity

To understand how cellular differentiation is coupled to withdrawal from the cell cycle, we have focused on two negative regulators of the cell cycle, the MYC antagonist MAD1 and the cyclin-dependent kinase inhibitor p27(KIP1). Generation of Mad1/p27(KIP1) double-null mice revealed a number of synth...

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Autori principali: McArthur, Grant A., Foley, Kevin P., Fero, Matthew L., Walkley, Carl R., Deans, Andrew J., Roberts, James M., Eisenman, Robert N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC133749/
https://ncbi.nlm.nih.gov/pubmed/11940659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.3014-3023.2002
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