Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP.

In familial Alzheimer's disease (FAD), missense point mutations V642I/F/G, which co-segregate with the disease phenotype, have been discovered in amyloid precursor APP695. Here, we report that three FAD mutants (FAD-APPs) negatively regulated the transcriptional activity of cAMP response elemen...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:EMBO J
Hlavní autoři: Ikezu, T, Okamoto, T, Komatsuzaki, K, Matsui, T, Martyn, J A, Nishimoto, I
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450179/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8665854/
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky