Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP.

In familial Alzheimer's disease (FAD), missense point mutations V642I/F/G, which co-segregate with the disease phenotype, have been discovered in amyloid precursor APP695. Here, we report that three FAD mutants (FAD-APPs) negatively regulated the transcriptional activity of cAMP response elemen...

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Détails bibliographiques
Auteurs principaux: Ikezu, T, Okamoto, T, Komatsuzaki, K, Matsui, T, Martyn, J A, Nishimoto, I
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC450179/
https://ncbi.nlm.nih.gov/pubmed/8665854
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