Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP.

In familial Alzheimer's disease (FAD), missense point mutations V642I/F/G, which co-segregate with the disease phenotype, have been discovered in amyloid precursor APP695. Here, we report that three FAD mutants (FAD-APPs) negatively regulated the transcriptional activity of cAMP response elemen...

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Detalles Bibliográficos
Publicado en:EMBO J
Autores principales: Ikezu, T, Okamoto, T, Komatsuzaki, K, Matsui, T, Martyn, J A, Nishimoto, I
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450179/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8665854/
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