G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

In familial Alzheimer's disease (FAD), three missense mutations, V642I, V642F and V642G, that co-segregate with the disease phenotype have been discovered in the 695 amino acid form of the amyloid precursor protein APP. Expression of these mutants causes a COS cell NK1 clone to undergo pertussi...

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Bibliografiske detaljer
Main Authors: Giambarella, U, Yamatsuji, T, Okamoto, T, Matsui, T, Ikezu, T, Murayama, Y, Levine, M A, Katz, A, Gautam, N, Nishimoto, I
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170125/
https://ncbi.nlm.nih.gov/pubmed/9305632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.16.4897
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