Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.

APP is a transmembrane precursor of beta-amyloid. In dominantly inherited familial Alzheimer's disease (FAD), point mutations V6421, V642F and V642G have been discovered in APP695. Here we show that expression of these mutants (FAD-APPs) causes a clone of COS cells to undergo apoptosis associat...

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Détails bibliographiques
Auteurs principaux: Yamatsuji, T, Okamoto, T, Takeda, S, Murayama, Y, Tanaka, N, Nishimoto, I
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC449968/
https://ncbi.nlm.nih.gov/pubmed/8599933
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