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Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.
APP is a transmembrane precursor of beta-amyloid. In dominantly inherited familial Alzheimer's disease (FAD), point mutations V6421, V642F and V642G have been discovered in APP695. Here we show that expression of these mutants (FAD-APPs) causes a clone of COS cells to undergo apoptosis associat...
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| Publicat a: | EMBO J |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
1996
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449968/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8599933/ |
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