Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.

APP is a transmembrane precursor of beta-amyloid. In dominantly inherited familial Alzheimer's disease (FAD), point mutations V6421, V642F and V642G have been discovered in APP695. Here we show that expression of these mutants (FAD-APPs) causes a clone of COS cells to undergo apoptosis associat...

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Main Authors: Yamatsuji, T, Okamoto, T, Takeda, S, Murayama, Y, Tanaka, N, Nishimoto, I
格式: Artigo
語言:Inglês
出版: 1996
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC449968/
https://ncbi.nlm.nih.gov/pubmed/8599933
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