SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

XPC recognizes UV-induced DNA lesions and initiates their removal by nucleotide excision repair (NER). Damage recognition in NER is tightly controlled by ubiquitin and SUMO modifications. Recent studies have shown that the SUMO-targeted ubiquitin ligase RNF111 promotes K63-linked ubiquitylation of S...

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Veröffentlicht in:Nat Commun
Hauptverfasser: van Cuijk, Loes, van Belle, Gijsbert J., Turkyilmaz, Yasemin, Poulsen, Sara L., Janssens, Roel C., Theil, Arjan F., Sabatella, Mariangela, Lans, Hannes, Mailand, Niels, Houtsmuller, Adriaan B., Vermeulen, Wim, Marteijn, Jurgen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501428/
https://ncbi.nlm.nih.gov/pubmed/26151477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8499
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