Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair

DNA damage sensors DDB2 and XPC initiate global genome nucleotide excision repair (NER) to protect DNA from mutagenesis caused by helix-distorting lesions. XPC recognizes helical distortions by binding to unpaired ssDNA opposite DNA lesions. DDB2 binds to UV-induced lesions directly and facilitates...

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發表在:Nat Commun
Main Authors: Ribeiro-Silva, Cristina, Sabatella, Mariangela, Helfricht, Angela, Marteijn, Jurgen A., Theil, Arjan F., Vermeulen, Wim, Lans, Hannes
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522231/
https://ncbi.nlm.nih.gov/pubmed/32985517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18705-0
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