Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair

DNA damage sensors DDB2 and XPC initiate global genome nucleotide excision repair (NER) to protect DNA from mutagenesis caused by helix-distorting lesions. XPC recognizes helical distortions by binding to unpaired ssDNA opposite DNA lesions. DDB2 binds to UV-induced lesions directly and facilitates...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Ribeiro-Silva, Cristina, Sabatella, Mariangela, Helfricht, Angela, Marteijn, Jurgen A., Theil, Arjan F., Vermeulen, Wim, Lans, Hannes
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522231/
https://ncbi.nlm.nih.gov/pubmed/32985517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18705-0
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