Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

Fifteen per cent of cancers maintain telomere length independently of telomerase by the homologous recombination (HR)-associated alternative lengthening of telomeres (ALT) pathway. A unifying feature of these tumours are mutations in ATRX. Here we show that expression of ectopic ATRX triggers a supp...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Clynes, David, Jelinska, Clare, Xella, Barbara, Ayyub, Helena, Scott, Caroline, Mitson, Matthew, Taylor, Stephen, Higgs, Douglas R., Gibbons, Richard J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Pub. Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501375/
https://ncbi.nlm.nih.gov/pubmed/26143912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8538
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