The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats

ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG)(n). ATRX mutations are found in nearly all tumours that maintain their telomeres via the alternative lengthening of telomere (ALT) pathway, and ATRX is known to suppress this path...

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Pubblicato in:EMBO Rep
Autori principali: Nguyen, Diu TT, Voon, Hsiao Phin J, Xella, Barbara, Scott, Caroline, Clynes, David, Babbs, Christian, Ayyub, Helena, Kerry, Jon, Sharpe, Jacqueline A, Sloane‐Stanley, Jackie A, Butler, Sue, Fisher, Chris A, Gray, Nicki E, Jenuwein, Thomas, Higgs, Douglas R, Gibbons, Richard J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452009/
https://ncbi.nlm.nih.gov/pubmed/28487353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643078
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