A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects

BACKGROUND: Although BRCA1 and BRCA2 mutations account for only ∼27% of the familial aggregation of ovarian cancer (OvC), no OvC risk prediction model currently exists that considers the effects of BRCA1, BRCA2 and other familial factors. Therefore, a currently unresolved problem in clinical genetic...

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Veröffentlicht in:J Med Genet
Hauptverfasser: Jervis, Sarah, Song, Honglin, Lee, Andrew, Dicks, Ed, Harrington, Patricia, Baynes, Caroline, Manchanda, Ranjit, Easton, Douglas F, Jacobs, Ian, Pharoah, Paul P D, Antoniou, Antonis C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2015
Schlagworte:
Cancer Genetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501173/
https://ncbi.nlm.nih.gov/pubmed/26025000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2015-103077
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