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The Contribution of Germline BRCA1 and BRCA2 Mutations to Familial Ovarian Cancer: No Evidence for Other Ovarian Cancer–Susceptibility Genes

To establish the contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer, we have analyzed both genes in DNA samples obtained from an affected individual in each of 112 families containing at least two cases of epithelial ovarian cancer. Germline mutations were found in 43% of...

詳細記述

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書誌詳細
主要な著者: Gayther, Simon A., Russell, Paul, Harrington, Patricia, Antoniou, Antonis C., Easton, Douglas F., Ponder, Bruce A. J.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society of Human Genetics 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288234/
https://ncbi.nlm.nih.gov/pubmed/10486320
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