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The Contribution of Germline BRCA1 and BRCA2 Mutations to Familial Ovarian Cancer: No Evidence for Other Ovarian Cancer–Susceptibility Genes

To establish the contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer, we have analyzed both genes in DNA samples obtained from an affected individual in each of 112 families containing at least two cases of epithelial ovarian cancer. Germline mutations were found in 43% of...

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Detalhes bibliográficos
Main Authors: Gayther, Simon A., Russell, Paul, Harrington, Patricia, Antoniou, Antonis C., Easton, Douglas F., Ponder, Bruce A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Human Genetics 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288234/
https://ncbi.nlm.nih.gov/pubmed/10486320
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