The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population

The aim of this study was to estimate the contribution of deleterious mutations in BRCA1, BRCA2, MLH1, MSH2, MSH6 and PMS2 to invasive epithelial ovarian cancer (EOC) in the population. The coding sequence and splice site boundaries of all six genes were amplified in germline DNA from 2240 invasive...

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Main Authors: Song, Honglin, Cicek, Mine S., Dicks, Ed, Harrington, Patricia, Ramus, Susan J., Cunningham, Julie M., Fridley, Brooke L., Tyrer, Jonathan P., Alsop, Jennifer, Jimenez-Linan, Mercedes, Gayther, Simon A., Goode, Ellen L., Pharoah, Paul D.P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2014
Ábhair:
Association Studies Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119409/
https://ncbi.nlm.nih.gov/pubmed/24728189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu172
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