The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population

The aim of this study was to estimate the contribution of deleterious mutations in BRCA1, BRCA2, MLH1, MSH2, MSH6 and PMS2 to invasive epithelial ovarian cancer (EOC) in the population. The coding sequence and splice site boundaries of all six genes were amplified in germline DNA from 2240 invasive...

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Hlavní autoři: Song, Honglin, Cicek, Mine S., Dicks, Ed, Harrington, Patricia, Ramus, Susan J., Cunningham, Julie M., Fridley, Brooke L., Tyrer, Jonathan P., Alsop, Jennifer, Jimenez-Linan, Mercedes, Gayther, Simon A., Goode, Ellen L., Pharoah, Paul D.P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Association Studies Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119409/
https://ncbi.nlm.nih.gov/pubmed/24728189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu172
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