The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population

The aim of this study was to estimate the contribution of deleterious mutations in BRCA1, BRCA2, MLH1, MSH2, MSH6 and PMS2 to invasive epithelial ovarian cancer (EOC) in the population. The coding sequence and splice site boundaries of all six genes were amplified in germline DNA from 2240 invasive...

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Detalhes bibliográficos
Main Authors: Song, Honglin, Cicek, Mine S., Dicks, Ed, Harrington, Patricia, Ramus, Susan J., Cunningham, Julie M., Fridley, Brooke L., Tyrer, Jonathan P., Alsop, Jennifer, Jimenez-Linan, Mercedes, Gayther, Simon A., Goode, Ellen L., Pharoah, Paul D.P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119409/
https://ncbi.nlm.nih.gov/pubmed/24728189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu172
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