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Artificial targeting of misfolded cytosolic proteins to endoplasmic reticulum as a mechanism for clearance
We report that misfolded cytosolic proteins can be cleared from mammalian cells by directing them to endoplasmic reticulum (ER). NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. We demonstrate...
Gorde:
| Argitaratua izan da: | Sci Rep |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4501007/ https://ncbi.nlm.nih.gov/pubmed/26168740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12088 |
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