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Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation.
Degradation of misfolded secretory proteins has long been assumed to occur in the lumen of the endoplasmic reticulum (ER). Recent evidence, however, suggests that such proteins are instead degraded by proteasomes in the cytosol, although it remains unclear how the proteins are transported out of the...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1997
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170080/ https://ncbi.nlm.nih.gov/pubmed/9303298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.15.4540 |
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