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Effect of grapefruit juice on the bioactivation of prasugrel

AIMS: The P2Y12 inhibitor prasugrel is a prodrug, which is activated after its initial hydrolysis partly by cytochrome P450 (CYP) 3A4. Grapefruit juice, a strong inactivator of intestinal CYP3A4, greatly reduces the activation and antiplatelet effects of clopidogrel. The aim of this study was to inv...

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Publicado en:Br J Clin Pharmacol
Autores principales: Holmberg, Mikko T, Tornio, Aleksi, Hyvärinen, Hanna, Neuvonen, Mikko, Neuvonen, Pertti J, Backman, Janne T, Niemi, Mikko
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Ltd 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500333/
https://ncbi.nlm.nih.gov/pubmed/25557052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12581
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