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Effect of grapefruit juice on the bioactivation of prasugrel
AIMS: The P2Y12 inhibitor prasugrel is a prodrug, which is activated after its initial hydrolysis partly by cytochrome P450 (CYP) 3A4. Grapefruit juice, a strong inactivator of intestinal CYP3A4, greatly reduces the activation and antiplatelet effects of clopidogrel. The aim of this study was to inv...
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| Izdano u: | Br J Clin Pharmacol |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley & Sons, Ltd
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500333/ https://ncbi.nlm.nih.gov/pubmed/25557052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12581 |
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