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Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin

AIMS: Simvastatin, a substrate for CYP3A4, is extensively metabolized during the first pass. Our aim was to investigate the effect of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin. METHODS: In a randomized cross-over study with two phases, 10 healthy volunteers inges...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Lilja, Jari J, Neuvonen, Mikko, Neuvonen, Pertti J
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Blackwell Science Inc 2004
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884539/
https://ncbi.nlm.nih.gov/pubmed/15206993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02095.x
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