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Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin

AIMS: Simvastatin, a substrate for CYP3A4, is extensively metabolized during the first pass. Our aim was to investigate the effect of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin. METHODS: In a randomized cross-over study with two phases, 10 healthy volunteers inges...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lilja, Jari J, Neuvonen, Mikko, Neuvonen, Pertti J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884539/
https://ncbi.nlm.nih.gov/pubmed/15206993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02095.x
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