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Effects of clarithromycin and grapefruit juice on the pharmacokinetics of glibenclamide
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Severe hypoglycaemia has been reported after concomitant use of clarithromycin and glibenclamide. Glibenclamide is a substrate for the transporters P-glycoprotein and OATP2B1. Clarithromycin inhibits P-glycoprotein and grapefruit juice inhibits OATP2B1. WHAT...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000598/ https://ncbi.nlm.nih.gov/pubmed/17223855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02836.x |
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