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Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8‐Mediated Metabolism of Montelukast in Humans

The oxidation of montelukast is mainly mediated by cytochrome P450 (CYP) 2C8, but other mechanisms may contribute to its disposition. In healthy volunteers, we investigated the effects of two widely used P2Y(12) inhibitors on montelukast pharmacokinetics. Clopidogrel (300 mg on day 1 and 75 mg on da...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacol Ther
Main Authors: Itkonen, Matti K., Tornio, Aleksi, Filppula, Anne M., Neuvonen, Mikko, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175296/
https://ncbi.nlm.nih.gov/pubmed/29171020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.947
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