Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.

The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled receptors are not well defined, the mechanisms of Ras activation by receptor tyrosine kinases have rec...

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Библиографические подробности
Опубликовано в: :EMBO J
Главные авторы: Chen, Y, Grall, D, Salcini, A E, Pelicci, P G, Pouysségur, J, Van Obberghen-Schilling, E
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 1996
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450000/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8605873/
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