Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.

The serine protease thrombin activates G protein signaling systems that lead to Ras activation and, in certain cells, proliferation. Whereas the steps leading to Ras activation by G protein-coupled receptors are not well defined, the mechanisms of Ras activation by receptor tyrosine kinases have rec...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Y, Grall, D, Salcini, A E, Pelicci, P G, Pouysségur, J, Van Obberghen-Schilling, E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC450000/
https://ncbi.nlm.nih.gov/pubmed/8605873
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