HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α

Many patients with hematological neoplasms fail to mobilize sufficient numbers of hematopoietic stem cells (HSCs) in response to granulocyte colony-stimulating factor (G-CSF) precluding subsequent autologous HSC transplantation. Plerixafor, a specific antagonist of the chemokine receptor CXCR4, can...

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Bibliographische Detailangaben
Veröffentlicht in:Leukemia
Hauptverfasser: Forristal, C E, Nowlan, B, Jacobsen, R N, Barbier, V, Walkinshaw, G, Walkley, C R, Winkler, I G, Levesque, J P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498452/
https://ncbi.nlm.nih.gov/pubmed/25578474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.8
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