Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in cancer cells are necessary for breast cancer progression. Here, we show that P4H alpha 1 subunit (P4HA1) protein expression is induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer. By modulating a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xiong, Gaofeng, Stewart, Rachel L., Chen, Jie, Gao, Tianyan, Scott, Timothy L., Samayoa, Luis M., O’Connor, Kathleen, Lane, Andrew N., Xu, Ren
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203834/
https://ncbi.nlm.nih.gov/pubmed/30367042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06893-9
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