Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases

An important regulator involved in oxygen-dependent gene expression is the transcription factor HIF (hypoxia-inducible factor), which is composed of an oxygen-sensitive α-subunit (HIF-1α or HIF-2α) and a constitutively expressed β-subunit. In normoxia, HIF-1α is destabilized by post-translational hy...

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Главные авторы: Marxsen, Jan H., Stengel, Petra, Doege, Kathrin, Heikkinen, Pekka, Jokilehto, Terhi, Wagner, Thomas, Jelkmann, Wolfgang, Jaakkola, Panu, Metzen, Eric
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2004
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133886/
https://ncbi.nlm.nih.gov/pubmed/15104534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040620
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