Channel Gating Dependence on Pore Lining Helix Glycine Residues in Skeletal Muscle Ryanodine Receptor

Type 1 ryanodine receptors (RyR1s) release Ca(2+) from the sarcoplasmic reticulum to initiate skeletal muscle contraction. The role of RyR1-G4934 and -G4941 in the pore-lining helix in channel gating and ion permeation was probed by replacing them with amino acid residues of increasing side chain vo...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Mei, Yingwu, Xu, Le, Mowrey, David D., Mendez Giraldez, Raul, Wang, Ying, Pasek, Daniel A., Dokholyan, Nikolay V., Meissner, Gerhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498087/
https://ncbi.nlm.nih.gov/pubmed/25998124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.659672
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