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DNA damage checkpoint kinase Chk2 triggers replicative senescence
Telomere shortening in normal human cells causes replicative senescence, a p53-dependent growth arrest state, which is thought to represent an innate defence against tumour progression. However, although it has been postulated that critical telomere loss generates a ‘DNA damage' signal, the sig...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2004
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC449769/ https://ncbi.nlm.nih.gov/pubmed/15192702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600259 |
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