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DNA damage checkpoint kinase Chk2 triggers replicative senescence
Telomere shortening in normal human cells causes replicative senescence, a p53-dependent growth arrest state, which is thought to represent an innate defence against tumour progression. However, although it has been postulated that critical telomere loss generates a ‘DNA damage' signal, the sig...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC449769/ https://ncbi.nlm.nih.gov/pubmed/15192702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600259 |
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