Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility

Since cAMP blocks meiotic maturation of mammalian and amphibian oocytes in vitro and cyclic nucleotide phosphodiesterase 3A (PDE3A) is primarily responsible for oocyte cAMP hydrolysis, we generated PDE3A-deficient mice by homologous recombination. The Pde3a(–/–) females were viable and ovulated a no...

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Bibliographische Detailangaben
Hauptverfasser: Masciarelli, Silvia, Horner, Kathleen, Liu, Chengyu, Park, Sun Hee, Hinckley, Mary, Hockman, Steven, Nedachi, Taku, Jin, Catherine, Conti, Marco, Manganiello, Vincent
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC449752/
https://ncbi.nlm.nih.gov/pubmed/15254586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421804
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