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Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility

Since cAMP blocks meiotic maturation of mammalian and amphibian oocytes in vitro and cyclic nucleotide phosphodiesterase 3A (PDE3A) is primarily responsible for oocyte cAMP hydrolysis, we generated PDE3A-deficient mice by homologous recombination. The Pde3a(–/–) females were viable and ovulated a no...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Masciarelli, Silvia, Horner, Kathleen, Liu, Chengyu, Park, Sun Hee, Hinckley, Mary, Hockman, Steven, Nedachi, Taku, Jin, Catherine, Conti, Marco, Manganiello, Vincent
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC449752/
https://ncbi.nlm.nih.gov/pubmed/15254586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421804
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