Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells

Hallmarks of cancer cells comprise altered glucose metabolism (aerobic glycolysis) and differences in DNA damage response (DDR). Glucose transporters (GLUT), glycolytic enzymes such as hexokinase (HK) and metabolic pathways (e.g. PI3K/Akt/mTor) have been shown to be upregulated in multiple myeloma a...

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發表在:Am J Cancer Res
Main Authors: Demel, Hans-Richard, Feuerecker, Benedikt, Piontek, Guido, Seidl, Christof, Blechert, Birgit, Pickhard, Anja, Essler, Markus
格式: Artigo
語言:Inglês
出版: e-Century Publishing Corporation 2015
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497433/
https://ncbi.nlm.nih.gov/pubmed/26175935
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