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The important role of VWF in platelet-derived FVIII gene therapy of murine hemophilia A in the presence of inhibitory antibodies
BACKGROUND: Our previous studies have demonstrated that targeting FVIII expression to platelets results in FVIII storage together with VWF in platelet α-granules and that platelet-derived FVIII (2bF8) corrects the murine hemophilia A phenotype even in the presence of high-titer anti-FVIII inhibitory...
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| Publicado no: | J Thromb Haemost |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4496307/ https://ncbi.nlm.nih.gov/pubmed/25955153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13001 |
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