Lentivirus-mediated platelet gene therapy of murine hemophilia A with pre-existing anti-FVIII immunity

BACKGROUND: The development of inhibitory antibodies, referred to as inhibitors, against exogenous FVIII in a significant subset of patients with hemophilia A remains a persistent challenge to the efficacy of protein replacement therapy. Our previous studies using the transgenic approach provided pr...

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Detalhes bibliográficos
Main Authors: Kuether, E. L., Schroeder, J. A., Fahs, S. A., Cooley, B. C., Chen, Y., Montgomery, R. R., Wilcox, D. A., Shi, Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419807/
https://ncbi.nlm.nih.gov/pubmed/22632092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2012.04791.x
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