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Comparison of platelet-derived and plasma FVIII efficacy using a novel native whole blood thrombin generation assay
BACKGROUND: We have recently developed a successful gene therapy approach for hemophilia A in which FVIII expression is targeted to platelets by the αIIb promoter. Levels of platelet expressed FVIII (2bF8) achieved by gene therapy may vary between individuals due to differences in ex vivo transducti...
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| Publicado no: | J Thromb Haemost |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4715732/ https://ncbi.nlm.nih.gov/pubmed/26453193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13169 |
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