Φορτώνει......
Increased P-gp inhibition at the human blood brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar
The permeability-glycoprotein (P-gp) efflux transporter is densely expressed at the blood-brain barrier (BBB) and its resultant ‘spare capacity’ requires substantial blockade to increase the uptake of avid substrates. This has blunted the ability of investigators to measure clinically meaningful alt...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Nucl Med |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4495896/ https://ncbi.nlm.nih.gov/pubmed/25500831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.114.146894 |
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