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Increased P-gp inhibition at the human blood brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar
The permeability-glycoprotein (P-gp) efflux transporter is densely expressed at the blood-brain barrier (BBB) and its resultant ‘spare capacity’ requires substantial blockade to increase the uptake of avid substrates. This has blunted the ability of investigators to measure clinically meaningful alt...
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| Publicado en: | J Nucl Med |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4495896/ https://ncbi.nlm.nih.gov/pubmed/25500831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.114.146894 |
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