Increased P-gp inhibition at the human blood brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar

The permeability-glycoprotein (P-gp) efflux transporter is densely expressed at the blood-brain barrier (BBB) and its resultant ‘spare capacity’ requires substantial blockade to increase the uptake of avid substrates. This has blunted the ability of investigators to measure clinically meaningful alt...

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Bibliografiske detaljer
Udgivet i:J Nucl Med
Main Authors: Kreisl, William C., Bhatia, Ritwik, Morse, Cheryl L., Woock, Alicia E., Zoghbi, Sami S., Shetty, H. Umesha, Pike, Victor W., Innis, Robert B.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495896/
https://ncbi.nlm.nih.gov/pubmed/25500831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.114.146894
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