FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC

CCDC6 gene product is a pro-apoptotic protein substrate of ATM, whose loss or inactivation enhances tumour progression. In primary tumours, the impaired function of CCDC6 protein has been ascribed to CCDC6 rearrangements and to somatic mutations in several neoplasia. Recently, low levels of CCDC6 pr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Morra, Francesco, Luise, Chiara, Merolla, Francesco, Poser, Ina, Visconti, Roberta, Ilardi, Gennaro, Paladino, Simona, Inuzuka, Hiroyuki, Guggino, Gianluca, Monaco, Roberto, Colecchia, David, Monaco, Guglielmo, Cerrato, Aniello, Chiariello, Mario, Denning, Krista, Claudio, Pier Paolo, Staibano, Stefania, Celetti, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494967/
https://ncbi.nlm.nih.gov/pubmed/25885523
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